SARS-CoV-2 (COVID-19) NSP3 Recombinant Protein

• Background:

  The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.

• Accession Number:

  QHD43415.1

• Tag:

  N-His Tag

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Infectious Disease, COVID-19

• Purity:

  >90% as determined by SDS-PAGE quantitative densitometry by Coomassie Blue Staining.

• Buffer:

  Supplied as lyophilized from PBS, pH 7.5. Please reconstitute the protein with ddH2O to the concentration with 1mg/ml.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 ˚ C for one week. Store at -20 to -80 ˚ C for twelve months from the date of receipt.

• Calculated Molecular Weight:

  22.03kDa

• Applications Notes:

  Immunogen

• Other Product Names:

  Nsp3, PL-PRO, Papain-like proteinase, X domain (Macro domain)

• Species:

  SARS-CoV-2

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3