SARS-CoV-2 (COVID-19) Delta Variant Spike S1 (His-Avi Tag) Recombinant Protein

• Background:

  SARS-CoV-2 delta variant, a variant of concern (VOC), known as B.1.617.2, was detected in India in October of 2020. However, it rapidly spread all over of the world and now it is the dominant variant in the world, which account for more than 99% of the cases. This variant carries at least 13 mutations in spike protein across the sub lineages, including L452R, D614G, P681R and K417N, which can increase the affinity to the human ACE2 receptor. Enhanced transmission of the Delta variant was observed globally, which is at least 2.5 times more contagious as the other variants. The Delta variant affects the effectiveness of COVID19 vaccine and is resistant to neutralization to some extent.

• NCBI Gene ID:

  43740578

• Swiss Prot:

  P0DTC1

• Accession Number:

  QHD43416.1

• Tag:

  His-Avi tag at C-terminus

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Infectious Disease, COVID-19

• Purity:

  > 90% as determined by Bis-Tris PAGE

• Buffer:

  PBS (pH 7.4) .

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  Store in working aliquots at -70˚ C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• Calculated Molecular Weight:

  120 kD

• Applications Notes:

  This recombinant protein can be used for WB and ELISA. For research use only.

• NCBI Official Name:

  Surface glycoprotein

• NCBI Organism:

  Severe acute respiratory syndrome coronavirus 2

• Background Reference 01:

  Zhang et al. JAMA 2021, 325 (13) : 1324-26.

• Background Reference 02:

  Reardon. Nature 2021.

• Background Reference 03:

  Delphine. Nature 2021, 596 (7871) : 276-280.

• Other Product Names:

  S protein RBD, Spike glycoprotein Receptor-binding domain, S glycoprotein RBD, Spike protein RBD, Delta variant spike RBD

• Tested Applications:

  ELISA, WB, SDS-PAGE

• Species:

  SARS-CoV-2 (COVID-19, 2019-nCoV) Spike Protein

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3