Poly Ig receptor Recombinant Protein

• Background:

  Polymeric immunoglobulin receptor (PIGR) is also known as Poly-Ig receptor, which can be cleaved into membrane secretory component (SC) . PIGR is a type I transmembrane glycoprotein or a member of the immunoglobulin superfamily, and is synthesized by secretory epithelial cells and delivered to the basolateral plasma membrane where it can bind larger polymers of IgA (pIgA) and pentameric IgM. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

• NCBI Gene ID:

  5284

• Swiss Prot:

  P01833

• Accession Number:

  AAI10495.1

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Immunology, Other

• Purity:

  >98% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  68.7 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Polymeric immunoglobulin receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Krajci P., et al., 1991, Hum. Genet. 87:642-648.

• Background Reference 02:

  Eiffert H., et al., 1984, Hoppe-Seyler's Z. Physiol. Chem. 365:1489-1495.

• Background Reference 03:

  Hughes G.J., et al., 1997, FEBS Lett. 410:443-446.

• Background Reference 04:

  Hamburger A.E., et al., 2004, Structure 12:1925-1935.

• Other Product Names:

  PIGR, Poly-Ig receptor

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3