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Toddacoumalone

CAT: 0804-HY-N10317Size: InquireDry Ice: NoHazardous: No
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CAT#:0804-HY-N10317Size:Inquire
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
139750-79-1
UNSPSC Description
Toddacoumalone is a natural inhibitor of phosphodiesterase 4 (PDE4) with moderate potency and imperfect agent-like properties. Toddacoumalone has the potential for the research of inflammatory diseases such as psoriasis[1].
Target Antigen
Phosphodiesterase (PDE)
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/toddacoumalone.html
Solubility
10 mM in DMSO
Smiles
C/C(C)=C\[C@H]1C2=C(O[C@](C)(C1)/C=C/C3=C4C(C=CC(O4)=O)=C(C=C3OC)OC)C5=CC=CC=C5N(C2=O)C
Molecular Weight
513.58
References & Citations
[1]Song Z, et al. Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis. J Med Chem. 2022;65(5):4238-4254.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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