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MIA Recombinant Protein

CAT: 0223-91-132Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-91-132Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Melanoma Inhibitory Activity Protein (MIA) is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells, which was the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family: MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3) -like domain. MIA acts as a potent tumor cell growth inhibitor for malignant melanoma cells and some other neuroectodermal tumors, including gliomas, in an autocrine fashion and promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extracellular matrix in vivo. The protein MIA has been shown to represent a very sensitive and specific serum marker for systemic malignant melanoma that might be useful for staging of primary melanomas, detection of progression from localized to metastatic disease during follow-up, and monitoring therapy of advanced melanomas. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis as well as a potential marker for rheumatoid arthritis.
CAS Number
9000-83-3
NCBI Gene ID
8190
Swiss Prot
Q16674
Accession Number
Q16674
Tag
C-6 His tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Obesity
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
13.31 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Melanoma inhibitory activity
NCBI Organism
Homo sapiens
Other Product Names
Melanoma-Derived Growth Regulatory Protein, Melanoma Inhibitory Activity Protein, MIA
Species
Human
Protein ID
767928039
Physical Properties
Lyophilized

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