LRP-6 (20-630) Recombinant Protein

• Background:

  LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. Low-density lipoprotein receptor-related protein 6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.

• NCBI Gene ID:

  4040

• Swiss Prot:

  O75581

• Accession Number:

  NP_002327.2

• Tag:

  Mouse IgG Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Purity:

  >90% as determined by SDS-PAGE.

• Buffer:

  Tris with Glycine, Arginine and NaCl, pH7.5

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  95.8 kDa

• Applications Notes:

  This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 95.8 kDa. The protein migrates as 55 kDa and 110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  LDLreceptorrelatedprotein6

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Williams BO, et al. 2009. J Bone Miner Res. 24 (2) :171-8.

• Background Reference 02:

  Li X, et al. 2005. J Biol Chem. 280 (20) :19883-7.

• Background Reference 03:

  Zeng X, et al. 2005. Nature. 438 (7069) :873-7.

• Other Product Names:

  LRP-6, LRP6

• Tested Applications:

  ELISA, WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3