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LILRB4 Recombinant Protein

CAT: 0223-96-809Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-96-809Size:0.1 mg
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Background
Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
CAS Number
9000-83-3
NCBI Gene ID
107128256
Swiss Prot
XP_015297198.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
28.0 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X1
NCBI Organism
Macaca fascicularis
Background Reference 01
Cella M., et al., 1997, J. Exp. Med. 185:1743-1751.
Background Reference 02
Chang C.C., et al., 2002, Nat. Immunol. 3:237-243.
Other Product Names
LILRB4, ILT3, LIR5, CD85K, HM18
Tested Applications
WB
Species
Cynomolgus monkey
Physical Properties
Lyophilized

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