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IL-17F Recombinant Protein

CAT: 0223-96-897Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-96-897Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Interleukin-17F (IL17F) is also known as Interleukin-24 (IL24), Cytokine ML-1, is a secreted disulfide-linked homodimer which belongs to the IL-17 family. There are at least six members of the IL-17 family in humans and in mice: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25) and IL-17F (also called IL-24) . IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. IL-17F / IL-24 is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. IL17F / Interleukin-24 stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. IL17F / IL-24 stimulates PBMC and T-cell proliferation and Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6) .
CAS Number
9000-83-3
NCBI Gene ID
112744
Swiss Prot
Q96PD4
Accession Number
AAH70124
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Chemokines & Cytokines, Growth Factors
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
15.7 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Interleukin 17F
NCBI Organism
Homo sapiens
Background Reference 01
Kolls JK, et al., 2004, Immunity 21 (4) : 467–76.
Background Reference 02
Ely L.K., et al., 2009, Nat. Immunol. 10:1245-1251.
Background Reference 03
Puel A., et al., 2011, Science 332:65-68.
Other Product Names
IL-17F, IL24, ML-1, Interleukin-17F
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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