LR3-IGF-1 Recombinant Protein

• Background:

  Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contains the N- and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids has 94% identity with mouse IGF-I and exhibits cross-species activity. IGF-1 binds IGF-IR, IGF-IIR, and the insulin receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. IGF-1 expression is regulated by growth hormone. R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg (R) for the Glu (E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. R3 IGF-1 has been produced with the purpose of increasing biological activity. R3 IGF-1 is significantly more potent than human IGF-I in vitro.

• NCBI Gene ID:

  3479

• Swiss Prot:

  P05019

• Accession Number:

  P05019

• Tag:

  Tag Free

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Other

• Buffer:

  Lyophilized from a 0.2 um filtered solution of 300mM HAc-NaAc, pH 6.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in 500mM Acetic Acid.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  9.1 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Insulin like growth factor 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Insulin-Like Growth Factor I, IGF-I, Mechano Growth Factor, MGF, Somatomedin-C, IGF1, IBP1

• Species:

  Human

• Protein ID:

  767957252

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3