IgG4 Fc Region Recombinant Protein

• Background:

  Immunoglobulin G4 (IgG4) is a member of many immunoglobulin G developed and secreted by effective B cells. In wake of cutting by pepsin, IgG is divided into two F (ab) s with one antigen binding site and a high conserved Fc segment. The Fc segment bears a highly conserved N-glycosylation site. Ig gamma-4 chain Fc region contains two constant regions of IgG4 H chain (CH2, CH3) .

• NCBI Gene ID:

  3503

• Swiss Prot:

  P01861

• Accession Number:

  P01861

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  Tris with Glycine, Arginine and NaCl, pH7.5

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  25.8 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Immunoglobulin heavy constant gamma 4 (G4m marker)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Frangione B., et al., 1969, Nature 221:145-148.

• Background Reference 02:

  Kristiansen T.Z., et al., 2004, Mol. Cell. Proteomics 3:715-728.

• Background Reference 03:

  Chen R., et al., 2009, J. Proteome Res. 8:651-661.

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3