G-CSF Recombinant Protein

Granulocyte colony-stimulating factor (G-CSF or GCSF) is also known as colony-stimulating factor 3, CSF3, C17orf33, CSF3OS, GCSF, MGC45931. It is a glycoprotein, growth factor and cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells. G-CSF then stimulates the bone marrow to release them into the blood. G-CSF also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. G-CSF regulates them using Janus kinase (JAK) /signal transducer and activator of transcription (STAT) and Ras /mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) /protein kinase B (Akt) signal transduction pathway. G-CSF is produced by endothelium, macrophages, and a number of other immune cells. The natural human glycoprotein exists in two forms, a 174- and 180-amino-acid-long protein of molecular weight 19,600 grams per mole. G-CSF can effect on the hematopoietic system and neuronal cells as a neurotrophic factor. The action of G-CSF in the central nervous system is to induce neurogenesis, to increase the neuroplasticity and to counteract apoptosis. G-CSF stimulates the production of white blood cells (WBC) . In oncology and hematology, a recombinant form of G-CSF is used with certain cancer patients to accelerate recovery from neutropenia after chemotherapy, allowing higher-intensity treatment regimens. Another form of recombinant human G-CSF called lenograstim is synthesised in Chinese Hamster Ovary cells (CHO cells) . The recombinant human G-CSF synthesised in an E. coli expression system is called filgrastim.

9000-83-3

1440

P09919

NP_757373.1

Tag Free

Recombinant Proteins

HEK293 cells

Chemokines & Cytokines

PBS, pH7.4

Room Temp

Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

18.7 kDa

This recombinant protein can be used for E, WB. For research use only.

Granulocyte colony-stimulating factor isoform b precursor

Homo sapiens

Schneider A, , et al., 2005, J. Clin. Invest. 115 (8) : 2083–98.

Pitzer C, et al., 2008, Brain 131 (Pt 12) : 3335–47.

G-CSF, CSF3, C17orf33, CSF3OS, MGC45931

ELISA, WB

Human