Frizzled-10 / FZD10 Recombinant Protein

• Background:

  Frizzled-10 (FZD10) is also known as FzE7 or CD350, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD10 contains one FZ (frizzled) domain. FZD10 protein is a cell surface receptor, which is activated by Wnt proteins and involved in the regulation of cellular function. FZD10 interacts with WNT7B and MYOC.

• NCBI Gene ID:

  11211

• Swiss Prot:

  Q9ULW2

• Accession Number:

  NP_009128.1

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Purity:

  >90% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  18.0 kDa

• Applications Notes:

  This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 18.0 kDa. The protein migrates as 22-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  Frizzledclassreceptor10

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Dorsam RT, Gutkind JS, Nat Rev Cancer. 2007 Feb; 7 (2) :79-94.

• Background Reference 02:

  Wang, Z. et al. (2005) Mol. Cell. Biol. 25:5022.

• Background Reference 03:

  Kwon HS, et al. Mol Cell Biol. 2009.

• Other Product Names:

  Fz-10, FZD10, hFz10, FzE7, CD350

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3