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E-Selectin Recombinant Protein

CAT: 0223-96-868Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0223-96-868Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
E-Selectin is also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), a member of the Selectin family, is a 107-115 kDa cell surface glycoprotein.[1] It is transiently expressed on vascular endothelial cells in response to IL-1beta and TNFalpha. E selectin has a cassette structure: an N-terminal, C-type lectin domain, an EGF (epidermal-growth-factor) -like domain, 6 Sushi domain (SCR repeat) units, a transmembrane domain (TM) and an intracellular cytoplasmic tail (cyto) .[2] During inflammation, E-selectin plays an important part in recruiting leukocytes to the site of injury. The local release of cytokines IL-1 and TNF-alpha by damaged cells induces the over-expression of E-selectin on endothelial cells of nearby blood vessels.[3] E-selectin mediates the adhesion of tumor cells to endothelial cells, by binding to E-selectin ligands expressed by neutrophils, monocytes, eosinophils, memory-effector T-like lymphocytes, natural killer cells or cancer cells. Furthermore, a number of studies have reported that levels of E-Selectin may be elevated in subjects with a variety of pathological conditions.
CAS Number
9000-83-3
NCBI Gene ID
6401
Swiss Prot
P16581
Accession Number
NP_000441.2
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Buffer
50 mM Tris, 100 mM Glycine, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
84.8 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
E-selectin precursor
NCBI Organism
Homo sapiens
Background Reference 01
Collins T, et al., 1991, J. Biol. Chem. 266 (4) : 2466–73.
Background Reference 02
Graves BJ, et al., 1994, Nature 367 (6463) : 532–8.
Background Reference 03
Robbins SL, et al., 1999, Philadelphia: WB Saunders. ISBN 0-7216-7335-X.
Other Product Names
SELE, RP1-117P20.2, CD62E, ELAM1, ESEL, LECAM2, E-Selectin
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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