Endothelial Cell Adhesion Molecule Recombinant Protein

• Background:

  Endothelial Cell Adhesion Molecule (ESAM) is a 55 kDa type I transmembrane glycoprotein member of the JAM family of immunoglobulin superfamily molecules. The 390 amino acid Human ESAM contains a 216 amino acid extracellular domain (ECD) with a V-type and a C2-type immunoglobulin (Ig) domain. ESAM is specifically expressed at endothelial tight junctions and on activated platelets and performs homophilic adhesion activity. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. In addition, ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. ESAM-deficient mice were described with lowered angiogenic potential, and accordingly, overexpression of ESAM is closely associated with certain tumor growth and metastasis. ESAM is expressed on endothelial cells, activated platelets and megakaryocytes. The ECD of human and mouse ESAM share 69% amino acid identity.

• NCBI Gene ID:

  90952

• Swiss Prot:

  Q96AP7

• Accession Number:

  Q96AP7

• Tag:

  C-6 His tag

• Type:

  Recombinant Proteins

• Source:

  Human Cells

• Field of Research:

  Cancer, Signal Transduction

• Buffer:

  Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.2. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  24.79 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Endothelial cell adhesion molecule

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Endothelial Cell-Selective Adhesion Molecule, ESAM

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3