CD26 Recombinant Protein

CAT: 0223-96-246Size: 0.05 mgDry Ice: NoHazardous: No
CAT#:0223-96-246Size:0.05 mg
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Background
Dipeptidyl peptidase-IV (DPPIV) is also known as adenosine deaminase complexing protein 2, DPPIV or CD26 is antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPPIV are proline (or alanine) -containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPPIV plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.[4] DPPIV also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.
CAS Number
9000-83-3
NCBI Gene ID
1803
Swiss Prot
P27487
Accession Number
NP_001926.2
Tag
N-Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Cell Cycle, Immunology, Obesity, Signal Transduction, Other
Purity
>95% as determined by SDS-PAGE.
Buffer
50 mM tris, 100 mM glycine, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
112 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Dipeptidyl-peptidase 4
NCBI Organism
Homo sapiens
Background Reference 01
Kameoka J, et al.,1993, Science, 261 (5120) : 466-9.
Background Reference 02
Chen X, 2006, Adv. Exp. Med. Biol. 575: 27–32.
Background Reference 03
Morimoto, C. et al., 1994, Proc. Natl. Acad. Sci. USA. 91: 9960-4.
Background Reference 04
Havre PA, et al., 2008, Front. Biosci. 13: 1634–45.
Other Product Names
DPP4, ADABP, ADCP2, CD26, DPPIV, TP103
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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