CD26 Recombinant Protein

• Background:

  Dipeptidyl peptidase-IV (DPPIV) is also known as adenosine deaminase complexing protein 2, DPPIV or CD26 is antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPPIV are proline (or alanine) -containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPPIV plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.[4] DPPIV also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.

• NCBI Gene ID:

  1803

• Swiss Prot:

  P27487

• Accession Number:

  NP_001926.2

• Tag:

  N-Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cancer, Cell Cycle, Immunology, Obesity, Signal Transduction, Other

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  50 mM tris, 100 mM glycine, pH7.5

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  112 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Dipeptidyl-peptidase 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kameoka J, et al.,1993, Science, 261 (5120) : 466-9.

• Background Reference 02:

  Chen X, 2006, Adv. Exp. Med. Biol. 575: 27–32.

• Background Reference 03:

  Morimoto, C. et al., 1994, Proc. Natl. Acad. Sci. USA. 91: 9960-4.

• Background Reference 04:

  Havre PA, et al., 2008, Front. Biosci. 13: 1634–45.

• Other Product Names:

  DPP4, ADABP, ADCP2, CD26, DPPIV, TP103

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3