DLL3 Recombinant Protein

• Background:

  Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands.May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues.

• NCBI Gene ID:

  10683

• Swiss Prot:

  Q9NYJ7

• Accession Number:

  NP_058637.1

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Other

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  PBS with Arginine, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  50.4 kDa

• Applications Notes:

  This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 50.4 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  Delta like canonical Notch ligand 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Tanaka K., et al. 2018, Lung Cancer., 115, 116-120.

• Background Reference 02:

  Laura R. Saunders., et al. 2015, Sci Transl Med., 26, 7 (302) .

• Background Reference 03:

  Zhang J., et al. 2017, Oncol Lett., 13 (6), 4533-4539.

• Other Product Names:

  Delta3, delta-like 3 (Drosophila), delta-like protein 3, DLL3, Pudgy, SCDO1, SCDO1delta3

• Tested Applications:

  ELISA, WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3