Contactin 2 Recombinant Protein

• Background:

  Contactin-2 is also known as CNTN2, TAX1 (transiently-expressed axonal glycoprotein), TAG1 (transient axonal glycoprotein), and axonin-1, and is a member of the immunoglobulin superfamily. CNTN2 consists of six Ig-like domains and four fibronectin type III domains, and is anchored to the membrane by glycosylphosphatidylinositol (GPI), whereas the soluble form can be released by a GPI-specific phospholipase. As a neural cell adhesion molecule expressed by a subset of neuronal populations in the developing CNS and PNS, CNTN2 mediates cell-cell interactions either via homophilic, or heterophilic contacts with various adhesion molecules including NgCAM, NrCAM, NCAM and neurocan. It is a glycosylphosphatidylinositol (GPI) -anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.

• NCBI Gene ID:

  6900

• Swiss Prot:

  Q02246

• Accession Number:

  NP_005067.1

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Cancer, Neuroscience

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  109 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Contactin 2 (axonal)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Tsiotra PC, et al., 1993, Genomics 18 (3) : 562–7. .

• Background Reference 02:

  Traka, M. et al., 2003, J. Cell. Biol. 162: 1161-1172.

• Background Reference 03:

  Mörtl M, ET AL., 2007, Protein Sci.16 (10) :2174-83.

• Other Product Names:

  CNTN2, AXT, DKFZp781D102, FLJ37193, FLJ42746, MGC157722, TAG-1, TAX, TAX1, Contactin-2

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3