CD74 Recombinant Protein

• Background:

  Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii) . CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.

• NCBI Gene ID:

  972

• Swiss Prot:

  P04233

• Accession Number:

  NP_004346.1

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Obesity, Signal Transduction, Other

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  19.3 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  CD74 molecule, major histocompatibility complex, class II invariant chain

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Cresswell P., 1994, Annu. Rev. Immunol. 12: 259–93.

• Background Reference 02:

  Charest A., et al., 2003, Genes Chromosomes Cancer 37:58-71.

• Background Reference 03:

  Leng L., et al., 2003, J. Exp. Med. 197:1467-1476.

• Other Product Names:

  CD74, DHLAG, HLADG, II, Ia-GAMMA, p33, CLIP, INVG34

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3