CD34 Recombinant Protein

CAT: 0223-11-132Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0223-11-132Size:0.1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD34 molecule is a cluster of differentiation molecule present on certain cells within the human body. It is a cell surface glycoprotein and functions as a cell-cell adhesion factor. It may also mediate the attachment of stem cells to bone marrow extracellular matrix or directly to stromal cells. As a ~ 110 kDa monomeric cell surface antigen, CD34 is highly glycosylated with nine potential N-linked and numerous potential O-linked glycosylation sites in its extracellular domain. The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early hematopoietic and vascular-associated tissue. CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes. It is expressed on lymph node endothelia whereas the L-selectin to which it binds is on the T cell. It was indicated that CD34 is a phosphorylation target for activated PKC, and couples to the hematopoietic adapter protein CrkL, which were involved in CD34 signaling pathways. CD34 is abberantly expressed in many kinds of tumors and is implicated in leukemogenesis.
CAS Number
9000-83-3
NCBI Gene ID
947
Swiss Prot
P28906
Accession Number
NP_001020280.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Signal Transduction, Stem Cell, Other
Purity
>90% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
29.4 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 29.4 kDa. The protein migrates as 67-96 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
CD34molecule
NCBI Organism
Homo sapiens
Background Reference 01
Simmons DL, et al., 1992, J. Immunol. 148 : 267–71.
Background Reference 02
Satterthwaite AB, et al., 1992, Genomics 12 (4) : 788–94.
Background Reference 03
Nielsen JS, McNagny KM., 2008, J of Cell Science 121 (Pt 22) : 3682–3692.
Background Reference 04
Berg EL, et al., 1998, Am. J. Pathol. 152 (2) : 469–77.
Other Product Names
CD34, RP11-328D5.2
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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