CD24 Recombinant Protein

• Background:

  CD24 may have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity.

• Tag:

  Fc Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Signal Transduction, Stem Cell, Other

• Purity:

  >90% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  29.3 kDa

• Applications Notes:

  This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 29.3 kDa. The protein migrates as 42-50 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.

• Background Reference 01:

  Suzuki T1, et al. 2001. J Immunol. 166 (9) :5567-77.

• Background Reference 02:

  Chen Z, et al. 2017. Biomed Pharmacother. 90:427-436.

• Background Reference 03:

  Eyvazi S, et al. 2018. Curr Cancer Drug Targets. 18 (4) :328-336.

• Other Product Names:

  CD24, CD24A

• Tested Applications:

  WB

• Species:

  Cynomolgus monkey

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3