CD24 Recombinant Protein

• Background :

  CD24 may have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity.

• CAS Number :

  9000-83-3

• Tag :

  Fc Tag

• Type :

  Recombinant Proteins

• Source :

  HEK293 cells

• Field of Research :

  Signal Transduction, Stem Cell, Other

• Purity :

  >90% as determined by SDS-PAGE.

• Buffer :

  PBS, pH7.4

• Shipping Conditions :

  Room Temp

• Storage Conditions :

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight :

  29.3 kDa

• Applications Notes :

  This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 29.3 kDa. The protein migrates as 42-50 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.

• Background Reference 01 :

  Suzuki T1, et al. 2001. J Immunol. 166 (9) :5567-77.

• Background Reference 02 :

  Chen Z, et al. 2017. Biomed Pharmacother. 90:427-436.

• Background Reference 03 :

  Eyvazi S, et al. 2018. Curr Cancer Drug Targets. 18 (4) :328-336.

• Other Product Names :

  CD24, CD24A

• Tested Applications :

  WB

• Species :

  Cynomolgus monkey

• Physical Properties :

  Lyophilized