Carbonic Anhydrase IX Recombinant Protein

• Background:

  Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes. CAs form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa), a reversible reaction that occurs rather slowly in the absence of a catalyst. One of the functions of the enzyme in animals is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues. The active site of most carbonic anhydrases contains a zinc ion. There are at least five distinct CA families (alpha, beta, γ, delta and epsilon) . Carbonic anhydrase 9 (CA9 / CAIX) is also known as Membrane antigen MN (MN), Renal cell carcinoma-associated antigen G250, which belongs to the alpha-carbonic anhydrase family. CA9 / CAIX with an optimal activity at pH 6.49. Reversible hydration of carbon dioxide. CA IX participates in pH regulation. CA9 may be involved in the control of cell proliferation and transformation. CA-IX appears to be a novel specific biomarker for a cervical neoplasia.

• NCBI Gene ID:

  768

• Swiss Prot:

  Q16790

• Accession Number:

  NP_001207.2

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Immunology

• Buffer:

  50 mM Tris, 150 mM NaCl, pH7.5

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  Protein MUST be be stored at -70˚ C or lower upon receipt. -70˚ C for 3 months under sterile conditions.

• Calculated Molecular Weight:

  30.9 kDa

• Applications Notes:

  This recombinant protein can be used for WB. For research use only.

• NCBI Official Name:

  Carbonic anhydrase 9 precursor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Badger MR, Price GD, 1994, Annu. Rev. Plant Physiol. Plant Mol. Bio. 45: 369–392.

• Background Reference 02:

  Temperini C., et al., 2007, Bioorg. Med. Chem. Lett. 17:2210-2215.

• Background Reference 03:

  Hilvo M., et al., 2008, J. Biol. Chem. 283:27799-27809.

• Background Reference 04:

  Alterio V., et al., 2009, Proc. Natl. Acad. Sci. U.S.A. 106:16233-16238.

• Other Product Names:

  CAIX, CA9, CA-IX, G250, MN, P54/58N, pMW1

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3