Bcl-xL Recombinant Protein

• Background:

  Bcl-2-Like Protein 1 (BCL2L1) is a member of the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a mitochondrial membrane protein. BCL2L1 contains four motifs, BH1, BH2 and BH4. The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. BCL2L1 regulates cell death by blocking the voltage-dependent anion channnel (VDAC) and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. In addition, BCL2L1 promotes apoptosis.

• NCBI Gene ID:

  598

• Swiss Prot:

  Q07817

• Accession Number:

  Q07817

• Tag:

  C-6 His tag

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Apoptosis, Cancer

• Buffer:

  Supplied as a 0.2 um filtered solution of 20mM HEPES, 50mM KCl, 20% Glycerol, pH 7.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

• Shipping Conditions:

  Dry Ice

• Calculated Molecular Weight:

  24.85 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  BCL2 like 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Bcl-2-Like Protein 1, Bcl2-L-1, Apoptosis Regulator Bcl-X, BCL2L1, BCL2L, BCLX

• Species:

  Human

• Protein ID:

  767904139

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3