BTLA Recombinant Protein

• Background:

  B- and T-Lymphocyte Attenuator (BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type (immunoglobulin-like) domain. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a lymphocyte inhibitory receptor that inhibits lymphocytes during immune response. BTLA also is a ligand for tumor necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM) . BTLA-HVEM complexes negatively regulate T-cell immune responses.

• NCBI Gene ID:

  151888

• Swiss Prot:

  Q7Z6A9

• Accession Number:

  Q7Z6A9

• Tag:

  C-Fc tag

• Type:

  Recombinant Proteins

• Source:

  Human Cells

• Field of Research:

  Immunology, Innate Immunity, Obesity

• Buffer:

  Lyophilized from a 0.2 um filtered solution of 20mM PB,150mM NaCl, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  40.8 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  B and T lymphocyte associated

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  B- and T-Lymphocyte Attenuator, B- and T-Lymphocyte-Associated Protein, CD272, BTLA

• Species:

  Human

• Protein ID:

  291219911

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3