Kanamycin kinase type II Recombinant Protein

• Background:

  Aminoglycoside 3'-phosphotransferase (APH (3') ), also known as aminoglycoside kinase, is an aminoglycoside-modifying enzyme and widely presented in resistant bacteria. These ATP-dependent enzymes phosphorylate the 3'-hydroxyl of a variety of aminoglycosides including kanamycins, neomycins, paromomycins, neamine, ribostamycin, geneticin, and paromamine. These phosphorylated aminoglycosides fail to bind to their respective ribosomal binding sites with high affinity; hence resistance is conferred to the drugs that are phosphorylated. APH (3') is primarily found in certain species of gram-positive bacteria.

• Swiss Prot:

  P00552

• Accession Number:

  P00552

• Tag:

  Tag Free

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Buffer:

  Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

• Shipping Conditions:

  Room Temp

• Calculated Molecular Weight:

  29 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Aminoglycoside 3'-phosphotransferase

• NCBI Organism:

  Klebsiella pneumoniae

• Other Product Names:

  Aminoglycoside 3'-phosphotransferase, APH (3') -II, APH (3') II, Kanamycin kinase type II, Neomycin-kanamycin phosphotransferase type II, neo

• Species:

  K. pneumoniae

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3