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Acetylcysteine

CAT: 0804-HY-B0215-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0215-01Size:500 mg
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Description
Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine ​​is the most stable form of cysteine ​​during drug delivery and can be used in disulfidptosis studies[1][2][3][4][5][6][7][8].
CAS Number
616-91-1
Product Name Alternative
N-Acetylcysteine; N-Acetyl-L-cysteine; NAC
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Disulfidptosis; Endogenous Metabolite; Ferroptosis; Influenza Virus; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Infection; Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Acetylcysteine.html
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
SC[C@@H](C(O)=O)NC(C)=O
Molecular Formula
C5H9NO3S
Molecular Weight
163.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Halasi M, et al. ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors. Biochem J. 2013 Sep 1;454 (2) :201-8.|[2]Ferrari G, et al. N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. J Neurosci. 1995 Apr;15 (4) :2857-66.|[3]Tsai JC, et al. Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells. J Biol Chem. 1996 Feb 16;271 (7) :3667-70.|[4]Yan CY, et al. Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway. J Neurosci. 1998 Jun 1;18 (11) :4042-9.|[5]Farr SA, et al. The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. J Neurochem. 2003 Mar;84 (5) :1173-83.|[6]Kalimeris K, et al. N-acetylcysteine ameliorates liver injury in a rat model of intestinal ischemia reperfusion. J Surg Res. 2016 Dec;206 (2) :263-272.|[7]Garigliany MM, et al. N-acetylcysteine lacks universal inhibitory activity against influenza A viruses. J Negat Results Biomed. 2011 May 9;10:5.|[8]Gu Q, et al. Disulfidptosis, a novel cell death pathway: molecular landscape and therapeutic implications[J]. Aging Dis, 2024, 10.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite

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