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HL389

CAT: 0804-HY-161770Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161770Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HL389 inhibits proliferation of cancer cells MDA-MB-231 and MCF-7, with IC50 of 11.39 μM and 9.66 μM. HL389 can be utilized as the ligand for E3 ligase for the synthesis of PROTAC degrader HL435.
UNSPSC
12352005
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hl389.html
Smiles
BrC(C=C1)=CC(/C=C(C(C=CC(C(F)(F)F)=C2)=C2N3)\C3=O)=C1OCC(OC(C)(C)C)=O
Molecular Formula
C22H19BrF3NO4
Molecular Weight
498.29
References & Citations
[1]Wang Y, et al., Alkenyl oxindole is a novel PROTAC moiety that recruits the CRL4DCAF11 E3 ubiquitin ligase complex for targeted protein degradation. PLoS Biol. 2024 May 20;22 (5) :e3002550.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

Alternative Products

CatalogName
T210249-01HL389
T210167-01HL389-NHC2-PEG3-C2NH

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