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Evybactin

CAT: 0804-HY-P3473Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P3473Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Evybactin is a DNA gyrase inhibitor. Evybactin is a selective inhibitor of Mycobacterium tuberculosis with a MIC value of 0.25 μg/mL. Evybactin is the first antimicrobial compound found to employ this unusual mechanism of selectivity[1].
UNSPSC
12352209
Target
Bacterial; DNA/RNA Synthesis
Type
Peptides
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/evybactin.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@H](C(N[C@@H](C(N[C@@H]([C@@H](C)OC(C[C@@H](C(O)=O)NC([C@H](CO)NC([C@H](NC(CNC([C@@H](NC([C@H](NC(C[C@H](NC([C@H](CC1=CN=CN1C)N2)=O)C(O)=O)=O)CO)=O)CC3=CC=CC=C3)=O)=O)CCCNC(N)=N)=O)=O)=O)C2=O)=O)CCCNC(N)=N)=O)[C@@H](C)O)[C@@H](NC=O)CC4=CNC5=CC=CC=C45
Molecular Formula
C64H89N21O21
Molecular Weight
1488.52
References & Citations
[1]Imai Y, et al. Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis. Nat Chem Biol. 2022 Aug 22.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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