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Tryptamine

CAT: 0804-HY-B2132-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B2132-01Size:100 mg
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Description
Tryptamine is a selective, blood-brain-penetrating 5-HT4 receptor agonist (EC50=1-3 mM) and an endogenous ligand of the aryl hydrocarbon receptor (AHR) (Kd=10-50 nM) . Tryptamine promotes intestinal anion secretion and fluid transport by activating G protein-coupled receptors (GPCRs) and accelerates gastrointestinal motility. Tryptamine regulates Th17/Treg balance to inhibit neuroinflammation, competitively binds to 5-HT receptors to regulate central nervous system activity, and participates in temperature regulation and spinal reflex regulation as a neuromodulator. Tryptamine can be used to study intestinal motility disorders such as functional constipation, and has shown significant efficacy in multiple sclerosis models[1][2][3].
CAS Number
[61-54-1]
Product Name Alternative
3- (2-Aminoethyl) indole~2- (3-Indolyl) ethylamine
UNSPSC
12352005
Hazard Statement
H302, H315, H318, H335
Target
5-HT Receptor; Aryl Hydrocarbon Receptor; Endogenous Metabolite
Type
Natural Products
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Tryptamine.html
Purity
99.95
Solubility
DMSO : ≥ 150 mg/mL
Smiles
NCCC1=CNC2=C1C=CC=C2
Molecular Formula
C10H12N2
Molecular Weight
160.22
Precautions
H302, H315, H318, H335
References & Citations
[1]Jones RS, et al. Tryptamine: a neuromodulator or neurotransmitter in mammalian brain? Prog Neurobiol. 1982;19 (1-2) :117-39.|[2]Dopkins N, et al. Tryptamine Attenuates Experimental Multiple Sclerosis Through Activation of Aryl Hydrocarbon Receptor. Front Pharmacol. 2021 Jan 25;11:619265.|[3]Bhattarai Y, et al. Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion. Cell Host Microbe. 2018 Jun 13;23 (6) :775-785.e5.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Phase 3
Isoform
Microbial Metabolite

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