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Rolipram (Standard)

CAT: 0804-HY-16900R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16900R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rolipram (Standard) is the analytical standard of Rolipram. This product is intended for research and analytical applications. Rolipram is a selective phosphodiesterases PDE4 inhibitor with IC50s of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
CAS Number
61413-54-5
Product Name Alternative
(R, S) -Rolipram (Standard) ; (±) -Rolipram (Standard) ; ZK 62711 (Standard)
UNSPSC
12352005
Target
Bacterial; HIV; Phosphodiesterase (PDE) ; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Others
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/rolipram-standard.html
Smiles
O=C1NCC(C2=CC=C(OC)C(OC3CCCC3)=C2)C1
Molecular Formula
C16H21NO3
Molecular Weight
275.34
References & Citations
[1]MacKenzie SJ, et al. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocyticcells. Biochem J. 2000 Apr|[2]Korhonen R, et al. Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1. Br J Pharmacol. 2013 Aug;169 (7) :1525-36.|[3]Shalaby AM, et al. Effect of rolipram, a phosphodiesterase enzyme type-4 inhibitor, on γ-amino butyric acid content of the frontal cortex in mice exposed to chronic mild stress. J Pharmacol Pharmacother. 2012 Apr;3 (2) :132-7.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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