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L 668411

CAT: 0804-HY-113725Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-113725Size:1 Each
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Description
L 668411 is a β-lactone inhibitor with activity against 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis. L 668411 inhibits rat liver cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase and [14C] acetate incorporation into sterols in cultured Hep G2 cells, and the inhibition appears to be irreversible in cells but reversible in cultured cells and animals.
CAS Number
112965-15-8
UNSPSC
12352005
Target
HMG-CoA Reductase (HMGCR)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/l-668411.html
Smiles
COC(/C=C(C)/C=C(C)/C[C@H](C)CCCC[C@@H]1[C@H](C(O1)=O)CO)=O
Molecular Formula
C19H30O5
Molecular Weight
338.44
References & Citations
[1]Inhibition of 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis by beta-lactone inhibitors and binding of these inhibitors to the enzyme
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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