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L803-mts

CAT: 0804-HY-P1173-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P1173-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L803-mts (Myristoylated L 803) is a selective and substrate-competitive GSK-3 peptide inhibitor (IC50: 40 μM) . L803-mts also reduces Aβ deposits and ameliorates cognitive deficits in 5XFAD mice. L803-mts shows antidepressive effect in the forced swimming test[1][2].
CAS Number
[706785-93-5]
Product Name Alternative
Myristoylated L 803; GSK-3β Inhibitor XIII
UNSPSC
12352209
Target
Amyloid-β; GSK-3
Type
Peptides
Related Pathways
Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/l803-mts.html
Purity
98.65
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C([C@H](CCC1)N1C([C@H](C)NC([C@H](CCC2)N2C([C@H](CCC3)N3C([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC(CNC(CCCCCCCCCCCCC)=O)=O)=O)=O)=O)=O)=O)=O)N(CCC4)[C@@H]4C(N[C@@H](CCC(N)=O)C(N[C@@H](CO[P](O)(O)=O)C(N(CCC5)[C@@H]5C(O)=O)=O)=O)=O
Molecular Formula
C66H109N14O21P
Molecular Weight
1465.63
References & Citations
[1]Kaidanovich-Beilin O, et al. Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus. Biol Psychiatry. 2004 Apr 15;55 (8) :781-4.|[2]Avrahami L, et al. Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies. J Biol Chem. 2013 Jan 11;288 (2) :1295-306.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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