Cloxacepride

CAT: 0804-HY-106645-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-106645-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Cloxacepride is an orally active and potent antiallergic agent. Cloxacepride is a CaM (calmodulin) antagonist. Cloxacepride has anti-PCA (passive cutaneous anaphylaxis) activity[1][2].

CAS Number

65569-29-1

UNSPSC

12352005

Target

Calmodulin

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cloxacepride.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(Cl)=C(NC(COC2=CC=C(C=C2)Cl)=O)C=C1OC)NCCN(CC)CC

Molecular Formula

C22H27Cl2N3O4

Molecular Weight

468.37

References & Citations

[1]Metz G, et al. Cloxacepride and related compounds: a new series of orally active antiallergic compounds. J Med Chem. 1983 Jul;26 (7) :1065-70. |[2]Friedrich G, et al. Inhibitory effect of cloxacepride on compound 48/80-induced histamine and serotonin release from rat mast cells. Arch Int Pharmacodyn Ther. 1984 Feb;267 (2) :264-8. |[3]Gigl G, et al. Calmodulin antagonism: a pharmacological approach for the inhibition of mediator release from mast cells. Cell Calcium. 1987 Oct;8 (5) :327-44.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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