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Nanaomycin A

CAT: 0804-HY-103397-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103397-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nanaomycin A is the first selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells[1]. Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM[2].
CAS Number
52934-83-5
UNSPSC
12352005
Hazard Statement
H301, H310
Target
Antibiotic; DNA Methyltransferase; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/nanaomycin-a.html
Purity
98.18
Solubility
10 mM in DMSO
Smiles
O=C(O)C[C@H]1CC(C(C2=C3C(O)=CC=C2)=O)=C(C3=O)[C@H](C)O1
Molecular Formula
C16H14O6
Molecular Weight
302.28
Precautions
H301, H310
References & Citations
[1]Kuck D, et al.Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells.Mol Cancer Ther. 2010 Nov;9 (11) :3015-23.|[2]Tanaka Y, et al.Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol.J Antibiot (Tokyo) . 1999 Oct;52 (10) :880-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DNMT3; Plasmodium

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