C-021 (dihydrochloride)

C-021 (dihydrochloride)

• CAS Number: 1784252-84-1
• UNSPSC Description: C-021 dihydrochloride is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 dihydrochloride effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM[1].
• Target Antigen: CCR
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Immunology/Inflammation
• Applications: Neuroscience-Neuromodulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/c-021-dihydrochloride.html
• Purity: 99.92
• Solubility: H2O : ≥ 27.0285 mg/mL|DMSO : 125 mg/mL (ultrasonic)
• Smiles: COC1=CC2=NC(N3CCC(N4CCCCC4)CC3)=NC(NC5CCCCCC5)=C2C=C1OC.[H]Cl.[H]Cl
• Molecular Weight: 540.57
• References & Citations: [1]Yokoyama K, et al. Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg Med Chem. 2009 Jan 1;17(1):64-73.|[2]Matthew McMillin, et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation. 2014 Jul 10;11:121.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported