Ceftazidime

• Description:

  Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases[1].

• Product Name Alternative:

  GR20263

• UNSPSC:

  12352005

• Hazard Statement:

  H317, H319, H334

• Target:

  Antibiotic; Bacterial; Beta-lactamase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Ceftazidime.html

• Purity:

  99.86

• Solubility:

  DMSO : 50 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1[C@@H] (NC (/C (C2=CSC (N) =N2) =N\OC (C) (C (O) =O) C) =O) [C@@]3 ([H]) SCC (C[N+]4=CC=CC=C4) =C (C ([O-]) =O) N13

• Molecular Formula:

  C22H22N6O7S2

• Molecular Weight:

  546.58

• Precautions:

  H317, H319, H334

• References & Citations:

  [1]Richards DM, et al. Ceftazidime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1985 Feb;29 (2) :105-61.|[2]Esmat Kamali, et al. In vitro activities of cellulase and ceftazidime, alone and in combination against Pseudomonas aeruginosa biofilms. BMC Microbiol. 2021 Dec 16;21 (1) :347. |[3]Qiuxia Lin, et al. Avibactam potentiated the activity of both ceftazidime and aztreonam against S. maltophilia clinical isolates in vitro. BMC Microbiol. 2021 Feb 22;21 (1) :60. |[4]Shawn H MacVane, et al. Unexpected in vivo activity of ceftazidime alone and in combination with avibactam against New Delhi metallo-β-lactamase-producing Enterobacteriaceae in a murine thigh infection model. Antimicrob Agents Chemother. 2014 Nov;58 (11) :7007-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  β-lactam

• CAS Number:

  72558-82-8