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HBC

CAT: 0804-HY-D1373-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-D1373-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HBC (HBC 530) is a GFP fluorophore-like synthetic dye, with a structurally rigid electron acceptor and a strong electron donor. HBC is nonfluorescent in solution, and when combined with Pepper (RNA aptamer), HBC forms a tight complex and activates and emits bright fluorescence (Kd of ~3.5 nM) . HBC emission peaks vary in different complexes and covers the spectrum from cyan to red. HBC can be used in the live cell imaging of RNA (Em/Ex = 530/485 nm) [1].
CAS Number
156840-13-0
Product Name Alternative
HBC 530
UNSPSC
12171500
Hazard Statement
H301, H319
Target
Fluorescent Dye
Type
Dye Reagents
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/hbc.html
Purity
99.69
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C(/C(C#N)=C\C2=CC=C(N(CCO)C)C=C2)C=C1
Molecular Formula
C19H17N3O
Molecular Weight
303.36
Precautions
H301, H319
References & Citations
[1]Chen X, et al. Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs. Nat Biotechnol. 2019;37 (11) :1287-1293.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Dye Reagents
Clinical Information
Phase 2

Chemical Information

CID 145712177
CAS Number156840-13-0
PubChem CID145712177
IUPAC Name4-[(E)-1-cyano-2-[4-[2-hydroxyethyl(methyl)amino]phenyl]ethenyl]benzonitrile
Molecular FormulaC19H17N3O
Molecular Weight303.4
XLogP2.9
Topological Polar Surface Area71.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count23
Formal Charge0
Complexity493
SMILES
CN(CCO)C1=CC=C(C=C1)/C=C(/C#N)\C2=CC=C(C=C2)C#N
InChI
InChI=1S/C19H17N3O/c1-22(10-11-23)19-8-4-15(5-9-19)12-18(14-21)17-6-2-16(13-20)3-7-17/h2-9,12,23H,10-11H2,1H3/b18-12-
InChIKey
DIAVZHWDYXQAFC-PDGQHHTCSA-N
Chemical Structure
2D Structure
2D structure of CID 145712177
CAS: 156840-13-0
CID: 145712177
Formula: C19H17N3O
MW: 303.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight303.4
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass303.137162174
Monoisotopic Mass303.137162174
Topological Polar Surface Area71.1 Ų
Heavy Atom Count23
Formal Charge0
Complexity493
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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