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NP213

CAT: 0804-HY-126810-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-126810-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NP213 is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 is effective and well-tolerated in resolving nail fungal infections[1][2].
CAS Number
942577-31-3
UNSPSC
12352209
Hazard Statement
H302-H315-H319
Target
Fungal
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/np213.html
Solubility
10 mM in DMSO
Smiles
N=C(N)NCCC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](N1)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C1=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O
Molecular Formula
C42H84N28O7
Molecular Weight
1093.30
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Mercer DK, et al. Improved Methods for Assessing Therapeutic Potential of Antifungal Agents against Dermatophytes and Their Application in the Development of NP213, a Novel Onychomycosis Therapy Candidate.Antimicrob Agents Chemother. 2019 Apr 25;63 (5) . pii: e02117-18|[2]Neelabh, et al. Sequential and Structural Aspects of Antifungal Peptides from Animals, Bacteria and Fungi Based on Bioinformatics Tools.Probiotics Antimicrob Proteins. 2016 Jun;8 (2) :85-101.|[3]Novamycin®/NP339 Technology Summary
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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CatalogName
TP2149L-01NP213
TP2149-01NP213 TFA (942577-31-3 free base)

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