GLP-1R/GIPR agonist-1

GLP-1R/GIPR agonist-1

• UNSPSC Description: GLP-1R/GIPR AgonIST-1 is a double-receptor agonist for GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulin releasing peptide). GLP-1R/GIPR agonist-1 lowers blood sugar by mimicking the action of endogenous hormones GLP-1 and GIP, enhancing insulin secretion while inhibiting glucagon secretion. GLP-1R/GIPR agonist-1 can be used in the study of metabolic diseases such as diabetes, obesity, and non-alcoholic steatohepatitis (NASH)[1].
• Target Antigen: GLP Receptor; Insulin Receptor
• Type: Peptides
• Related Pathways: GPCR/G Protein;Protein Tyrosine Kinase/RTK
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/glp-1r-gipr-agonist-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NC(CCC(NCCOCCOCC(NCCOCCOCC(NCCCCC(NC([C@H](C)NC([C@H](C)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@@H](NC(C(C)(C)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC1=CC=C(C=C1)O)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H](CC2=CC=CC=C2)NC([C@H]([C@H](O)C)NC(CNC([C@H](CCC(N)=O)NC(C(C)(C)NC([C@H](CC3=CNC=N3)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(NCC(NCC(N7[C@@H](CCC7)C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(N[C@@H](C)C(N8[C@@H](CCC8)C(N9[C@@H](CCC9)C(N%10[C@@H](CCC%10)C(N[C@@H](CO)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(O)=O)CCCCCCCCCCCCCCCCC(O)=O
• Molecular Weight: 4861.38
• References & Citations: [1]Liu C, et al. Discovery of a novel GLP-1/GIP dual receptor agonist CY-5 as long-acting hypoglycemic, anti-obesity agent[J]. Bioorganic Chemistry, 2021, 106: 104492.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported