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TC11

CAT: 0804-HY-129478-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-129478-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TC11 is a MCL1 degrader and Caspase-9 and CDK1 activator. TC11 functions as a phenylacetylamide derivative and is structurally related to immunomodulatory active molecules. TC11 induces degradation of MCL1 leading to apoptotic death [1][2] during prolonged mitotic arrest.
CAS Number
100823-03-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bcl-2 Family; Caspase; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tc11.html
Concentration
10mM
Purity
99.55
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1N(C2=C(C(C)C)C=CC=C2C(C)C)C(C3=C1C=CC(N)=C3)=O
Molecular Formula
C20H22N2O2
Molecular Weight
322.40
Precautions
H302, H315, H319, H335
References & Citations
[1] Ichikawa D, et al. A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells. Biochem Biophys Res Commun. 2020;521 (1) :252-258.|[2]Shiheido H, et al. A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma. PLoS One. 2012;7 (6) :e38878.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 9; CDK1; Mcl-1

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