Terbinafine

• UNSPSC Description:

  Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria[1][2][3]. Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• Target Antigen:

  Antibiotic; Bacterial; Fungal

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/Terbinafine.html

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  CN(C/C=C/C#CC(C)(C)C)CC1=C2C=CC=CC2=CC=C1

• Molecular Weight:

  291.43

• References & Citations:

  [1]Ryder NS, et al. Terbinafine: mode of action and properties of the squalene epoxidase inhibition. Br J Dermatol. 1992 Feb;126 Suppl 39:2-7.|[2]Mieth H, et al. Preclinical evaluation of terbinafine in vivo. Clin Exp Dermatol. 1989 Mar;14(2):104-7.|[3]Ciftci E, et al. Mupirocin vs terbinafine in impetigo.Indian J Pediatr. 2002 Aug;69(8):679-82.Adv Healthc Mater. 2023 May 20;e2300018.|Adv Sci (Weinh). 2023 Sep;10(27):e2206878.|bioRxiv. 2024 May 14.|Cancer Commun (Lond). 2021 Jul 16.|Clin Transl Med. 2024 Feb;14(2):e1586.|Infect Drug Resist. 2022: 7459-7473.|Nat Microbiol. 2024 Feb;9(2):346-358.|Research Square Preprint. 2023 Sep 26.|Cancer Res. 2022 Sep 2;82(17):3032-3044.|Cell Death Dis. 2021 May 13;12(5):482.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Launched

• CAS Number:

  91161-71-6