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Hepcidin-20 (human)

CAT: 0804-HY-P4370Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P4370Size:1 Each
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Description
Hepcidin-20 (human) is a histidine-containing, cysteine-rich, β-sheet structured peptide. Hepcidin-20 (human) shows antifungal activity. Hepcidin-20 (human) inhibits biofilm formation and bacterial cell metabolism of polysaccharide intercellular adhesin (PIA) -positive and PIA-negative strains[1][2][3].
CAS Number
342790-23-2
UNSPSC
12352209
Target
Bacterial; Fungal; Hepcidin
Type
Peptides
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hepcidin-20-human.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@H](C(N[C@H](C(N[C@H]1CCCCN)=O)CO)=O)CCCNC(N)=N)[C@@H](NC([C@@](CSSC[C@](C(NCC(N[C@H]2CCSC)=O)=O)([H])NC1=O)([H])NC([C@](NC(CNC([C@@](CSSC[C@](C(N3)=O)([H])NC2=O)([H])NC([C@@](CSSC[C@H]3C(N[C@@H](CCCCN)C(N[C@H](C(O)=O)[C@H](O)C)=O)=O)([H])NC4=O)=O)=O)=O)([H])CSSC[C@@H](C(N[C@@](C(N[C@H]4CC5=CC=CC=C5)=O)([H])[C@@H](C)CC)=O)NC([C@@H](N)[C@@H](C)CC)=O)=O)=O)CC6=CN=CN6
Molecular Formula
C85H135N27O23S9
Molecular Weight
2191.73
References & Citations
[1]Maisetta G, et al. pH-dependent disruption of Escherichia coli ATCC 25922 and model membranes by the human antimicrobial peptides hepcidin 20 and 25. FEBS J. 2013 Jun;280 (12) :2842-54. |[2]Del Gaudio G, et al. Antifungal Activity of the Noncytotoxic Human Peptide Hepcidin 20 against Fluconazole-Resistant Candida glabrata in Human Vaginal Fluid. Antimicrob Agents Chemother. 2013 Sep;57 (9) :4314-4321.|[3]Brancatisano FL, et al. Inhibitory effect of the human liver-derived antimicrobial peptide hepcidin 20 on biofilms of polysaccharide intercellular adhesin (PIA) -positive and PIA-negative strains of Staphylococcus epidermidis. Biofouling. 2014;30 (4) :435-46.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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