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Luseogliflozin

CAT: 0804-HY-10449-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10449-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Luseogliflozin (TS 071) is a potent, selective, orally active sodium-dependent glucose cotransporter (SGLT) 2 inhibitor, with an IC50 of 2.26 nM, about 1765-fold selectivity over SGLT1 (IC50, 3990 nM) . Luseogliflozin has the protential for researching type 2 diabetes[1][2].
CAS Number
898537-18-3
Product Name Alternative
TS 071
UNSPSC
12352005
Target
SGLT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Luseogliflozin.html
Purity
99.33
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
OC[C@@H](S1)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1C2=C(OC)C=C(C)C(CC3=CC=C(OCC)C=C3)=C2
Molecular Formula
C23H30O6S
Molecular Weight
434.55
References & Citations
[1]Anthony Markham, et al. Luseogliflozin: first global approval. Drugs. 2014 Jun;74 (8) :945-50.|[2]Jun Shirakawa, et al. Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway. Diabetologia. 2020 Mar;63 (3) :577-587.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
SGLT1; SGLT2

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A13476-5Luseogliflozin 5mg
A13476-10Luseogliflozin 10mg
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