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MEK-5 rabbit pAb

CAT: 0855-ES20665-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES20665-01Size:50 µL
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Background
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs) . The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]
Description
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011],
UniProt
Q13163
Swiss Prot
Q13163
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Protein of MEK-5
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF
Dilution
WB: 1:1000-2000 IHC: 1:200-500
Molecular Weight
49kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
49kD
Fragment
IgG
Subcellular Location
Nucleus, cytoplasm, spindle, cytosol
Other Product Names
MAP2K5; MEK5; MKK5; PRKMK5; Dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAPKK 5; MAPK/ERK kinase 5; MEK 5
Gene ID (Human)
5067

UniProtKB · Q13163

Dual specificity mitogen-activated protein kinase kinase 5

MP2K5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13163
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAP2K5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MAP kinase kinase 5, MAPKK 5
EC number
2.7.12.2
Processing
—
Secondary accessions
B4DE43, Q92961, Q92962
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Molecular function

KinaseSerine/threonine-protein kinaseTransferaseTyrosine-protein kinase

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