Piribedil

CAT: 0804-HY-12707-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-12707-01Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Piribedil is a potent and orally active dopamine D2 and dopamine D3 agonist. Piribedil is also a α2-adrenoceptors antagonist. Piribedil can inhibit MLL1 methyltransferase activity (EC50: 0.18 μM) . Piribedil has the potential for the research of parkinson's disease, circulatory disorders, cancers[1][2][3][4].

CAS Number

3605-01-4

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adrenergic Receptor; Dopamine Receptor; Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics; GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Piribedil.html

Purity

99.92

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

C1(N2CCN(CC3=CC=C(OCO4)C4=C3)CC2)=NC=CC=N1

Molecular Formula

C16H18N4O2

Molecular Weight

298.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Sweet RD, et al. Piribedil, a dopamine agonist, in Parkinson's disease. Clin Pharmacol Ther. 1974 Dec;16 (6) :1077-82. |[2]Gerlach M, et al. The effect of piribedil on L-DOPA-induced dyskinesias in a rat model of Parkinson's disease: differential role of α (2) adrenergic mechanisms. J Neural Transm (Vienna) . 2013 Jan;120 (1) :31-6. |[3]Smith LA, Tet al. Repeated administration of piribedil induces less dyskinesia than L-dopa in MPTP-treated common marmosets: a behavioural and biochemical investigation. Mov Disord. 2002 Sep;17 (5) :887-901.|[4]Xiong Zhang, et al. Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis. Cancer Lett. 2018 Sep 1;431:150-160.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

D2 Receptor; D3 Receptor; α adrenergic receptor

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B8904-100	Piribedil
B6557-100	Piribedil dihydrochloride
T12486-01	Piribedil D8

Piribedil

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