Piribedil

• Description :

  Piribedil is a potent and orally active dopamine D2 and dopamine D3 agonist. Piribedil is also a α2-adrenoceptors antagonist. Piribedil can inhibit MLL1 methyltransferase activity (EC50: 0.18 μM) . Piribedil has the potential for the research of parkinson's disease, circulatory disorders, cancers[1][2][3][4].

• CAS Number :

  [3605-01-4]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Adrenergic Receptor; Dopamine Receptor; Histone Methyltransferase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cancer; Endocrinology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Piribedil.html

• Purity :

  99.92

• Solubility :

  DMSO : 33.33 mg/mL (ultrasonic)

• Smiles :

  C1(N2CCN(CC3=CC=C(OCO4)C4=C3)CC2)=NC=CC=N1

• Molecular Formula :

  C16H18N4O2

• Molecular Weight :

  298.34

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Sweet RD, et al. Piribedil, a dopamine agonist, in Parkinson's disease. Clin Pharmacol Ther. 1974 Dec;16 (6) :1077-82. |[2]Gerlach M, et al. The effect of piribedil on L-DOPA-induced dyskinesias in a rat model of Parkinson's disease: differential role of α (2) adrenergic mechanisms. J Neural Transm (Vienna) . 2013 Jan;120 (1) :31-6. |[3]Smith LA, Tet al. Repeated administration of piribedil induces less dyskinesia than L-dopa in MPTP-treated common marmosets: a behavioural and biochemical investigation. Mov Disord. 2002 Sep;17 (5) :887-901.|[4]Xiong Zhang, et al. Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis. Cancer Lett. 2018 Sep 1;431:150-160.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  D2 Receptor; D3 Receptor; α adrenergic receptor