Nortadalafil

• Description:

  Nortadalafil (Demethyl Tadalafil), a tadalafil (HY-90009A) analogue detected in health foods, is a highly selective PDE5 inhibitor. Nortadalafil is used in the research of erectile dysfunction (ED) . Nortadalafil can be formed by closing the diketopiperazine ring in high yield. Nortadalafil is promising for research of pulmonary arterial hypertension[1][2][3][4][5][6].

• Product Name Alternative:

  Demethyl Tadalafil

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Nortadalafil.html

• Purity:

  99.71

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C1NCC(N([C@@H]1C2)[C@H](C3=CC=C(OCO4)C4=C3)C5=C2C6=C(N5)C=CC=C6)=O

• Molecular Formula:

  C21H17N3O4

• Molecular Weight:

  375.38

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Daugan, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogue. Journal of Medicinal Chemistry (2003), 46 (21), 4533-4542.|[2]Porst H, et al. Chronic PDE-5 inhibition in patients with erectile dysfunction - a treatment approach using tadalafil once-daily. Expert Opin Pharmacother. 2012 Jul;13 (10) :1481-94.|[3]Frey MK, Lang I. Tadalafil for the treatment of pulmonary arterial hypertension. Expert Opin Pharmacother. 2012 Apr;13 (5) :747-55.|[4]HUANG ZHi, et al. Discovery of Nortadalafil in Health Foods[J]. Chinese Pharmaceutical Journal, 2015, 50 (4) : 371-374.|[5]Fukiwake T, et al. [The Configuration of Tadalafil and Tadalafil Analogues Found in Dietary Supplements][J]. Shokuhin Eiseigaku Zasshi. 2021;62 (2) :65-72. |[6]Beghyn T, et al. PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil. Bioorg Med Chem Lett[J]. 2007 Feb 1;17 (3) :789-92.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PDE5

• CAS Number:

  [171596-36-4]