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Nortadalafil

CAT: 0804-HY-90009-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-90009-01Size:5 mg
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Description
Nortadalafil (Demethyl Tadalafil), a tadalafil analogue detected in health foods, is a highly selective PDE5 inhibitor. Nortadalafil is used in the research of erectile dysfunction (ED). Nortadalafil can be formed by closing the diketopiperazine ring in high yield. Nortadalafil is promising for research of pulmonary arterial hypertension[1][2][3][4][5][6].
CAS Number
171596-36-4
Product Name Alternative
Demethyl Tadalafil
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Nortadalafil.html
Purity
99.71
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1NCC(N([C@@H]1C2)[C@H](C3=CC=C(OCO4)C4=C3)C5=C2C6=C(N5)C=CC=C6)=O
Molecular Formula
C21H17N3O4
Molecular Weight
375.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Daugan, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogue. Journal of Medicinal Chemistry (2003), 46 (21), 4533-4542.|[2]Porst H, et al. Chronic PDE-5 inhibition in patients with erectile dysfunction - a treatment approach using tadalafil once-daily. Expert Opin Pharmacother. 2012 Jul;13 (10) :1481-94.|[3]Frey MK, Lang I. Tadalafil for the treatment of pulmonary arterial hypertension. Expert Opin Pharmacother. 2012 Apr;13 (5) :747-55.|[4]HUANG ZHi, et al. Discovery of Nortadalafil in Health Foods[J]. Chinese Pharmaceutical Journal, 2015, 50 (4) : 371-374.|[5]Fukiwake T, et al. [The Configuration of Tadalafil and Tadalafil Analogues Found in Dietary Supplements][J]. Shokuhin Eiseigaku Zasshi. 2021;62 (2) :65-72. |[6]Beghyn T, et al. PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil. Bioorg Med Chem Lett[J]. 2007 Feb 1;17 (3) :789-92.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE5

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