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LY310762

CAT: 0804-HY-13527-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13527-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY310762 is a selective 5-HT1D receptor antagonist (Ki=249 nM) with a weak affinity for 5-HT1B receptor. LY310762 effectively abolishes the renal vasodilatory effects of 5-HT[1][2][3].
CAS Number
192927-92-7
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/LY310762.html
Purity
98.68
Solubility
DMSO : 18.33 mg/mL (ultrasonic)
Smiles
O=C1N(CCN2CCC(C(C3=CC=C(F)C=C3)=O)CC2)C4=C(C=CC=C4)C1(C)C.[H]Cl
Molecular Formula
C24H28ClFN2O2
Molecular Weight
430.94
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Pullar IA, et al. The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig. Eur J Pharmacol. 2004 Jun 16;493 (1-3) :85-93. |[2]García-Pedraza JÁ, et al. Pharmacological evidence that 5-HT1D activation induces renal vasodilation by NO pathway in rats. Clin Exp Pharmacol Physiol. 2015 Jun;42 (6) :640-7. |[3]Choi IS, Cho JH, An CH, Jung JK, Hur YK, Choi JK, Jang IS. 5-HT (1B) receptors inhibit glutamate release from primary afferent terminals in rat medullary dorsal horn neurons. Br J Pharmacol. 2012 Sep;167 (2) :356-67.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; mLAG-3

Alternative Products

CatalogName
B2250-10LY310762
A11106-200LY310762 200mg
C08765LY310762 HCl
A11106-10LY310762 10mg
A11106-100LY310762 100mg
A11106-50LY310762 50mg
A11106-25LY310762 25mg
A11106-5LY310762 5mg
A11106-10mM-DLY310762 10mM * 1mL in DMSO

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