(-) -Blebbistatin

• Description :

  (-) -Blebbistatin is a selective inhibitor of the ATPase activity of non-muscle myosin II[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Myosin

• Type :

  Reference compound

• Related Pathways :

  Cytoskeleton

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cardiovascular Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/_-_-Blebbistatin.html

• Purity :

  99.42

• Solubility :

  DMSO : 10 mg/mL (ultrasonic)

• Smiles :

  CC1=CC=C(N=C(N(C2=CC=CC=C2)CC3)[C@]3(O)C4=O)C4=C1

• Molecular Formula :

  C18H16N2O2

• Molecular Weight :

  292.34

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Cristina Lucas‐Lopez, et al. Absolute Stereochemical Assignment and Fluorescence Tuning of the Small Molecule Tool, (–) ‐Blebbistatin.|[2]Ponsaerts R, et al. The myosin II ATPase inhibitor blebbistatin prevents thrombin-induced inhibition of intercellularcalcium wave propagation in corneal endothelial cells. Invest Ophthalmol Vis Sci. 2008 Nov;49 (11) :4816-27.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [856925-71-8]