(-) -Blebbistatin

• Description:

  (-) -Blebbistatin is a selective inhibitor of the ATPase activity of non-muscle myosin II[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Myosin

• Type:

  Reference compound

• Related Pathways:

  Cytoskeleton

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/_-_-Blebbistatin.html

• Purity:

  99.42

• Solubility:

  DMSO : 10 mg/mL (ultrasonic)

• Smiles:

  CC1=CC=C(N=C(N(C2=CC=CC=C2)CC3)[C@]3(O)C4=O)C4=C1

• Molecular Formula:

  C18H16N2O2

• Molecular Weight:

  292.34

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Cristina Lucas‐Lopez, et al. Absolute Stereochemical Assignment and Fluorescence Tuning of the Small Molecule Tool, (–) ‐Blebbistatin.|[2]Ponsaerts R, et al. The myosin II ATPase inhibitor blebbistatin prevents thrombin-induced inhibition of intercellularcalcium wave propagation in corneal endothelial cells. Invest Ophthalmol Vis Sci. 2008 Nov;49 (11) :4816-27.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [856925-71-8]