Anti-Hu CD123 PerCP

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: No

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Anti-Hu CD123 PerCP

CAT:

270-PC-700-T100

Size:

100 Tests

Price:

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For price, please contact [email protected].

Anti-Hu CD123 PerCP

Background: CD123 is the alpha chain of interleukin 3 receptor (IL-3R alpha). This subunit heterodimerizes with the interleukin 3 receptor beta chain (CD131), which is shared with other receptors. CD123 interacts with IL-3 specifically, but with low affinity, and association with the beta subunit confers high affinity binding to the receptor heterodimer. Both chains are required for signaling, but receptor activation and signal transduction depend on IL-3 binding to CD123 as the initial step.
Specifications: The mouse monoclonal antibody 6H6 recognizes an extracellular epitope of CD123 (interleukin 3 receptor alpha), a 60-70 kDa transmembrane protein expressed by myeloid precursors, megakaryocytes, macrophages, dendritic cells, mast cells, basophils, and some B cells. This antibody does not inhibit IL-3 binding to its receptor.
Certification: RUO
Host: Mouse
Species Reactivity: Human
Immunogen: IL3 receptor alpha chain expressed on the surface of transiently transfected COS cells
Target Antigen: CD123
Isotype: IgG1
Clone: 6H6
Applications: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 mL) is sufficient for 100 tests.
Validated Applications: FC
Format: PerCP
Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *Sun Q, Woodcock JM, Rapoport A, Stomski FC, Korpelainen EI, Bagley CJ, Goodall GJ, Smith WB, Gamble JR, Vadas MA, Lopez AF: Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist. Blood. 1996 Jan 187(1):83-92., URL: https://pubmed.ncbi.nlm.nih.gov/8547680/,*Martín-Gayo E, Sierra-Filardi E, Corbí AL, Toribio ML: Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development. Blood. 2010 Jul 1115(26):5366-75., URL: http://www.ncbi.nlm.nih.gov/pubmed/20357241 ,*Herling M, Teitell MA, Shen RR, Medeiros LJ, Jones D: TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin. Blood. 2003 Jun 15101(12):5007-9., URL: http://www.ncbi.nlm.nih.gov/pubmed/12576313 ,
Storage Conditions: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Complementary Product Range

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Cat	Name
PC-700-T100	Anti-Hu CD123 PerCP
T9-700-T100	Anti-Hu CD123 PerCP-Cy1535.5
T9-700-T025	Anti-Hu CD123 PerCP-Cy1535.5
1B-700-C100	Anti-Hu CD123 Biotin
1P-700-T025	Anti-Hu CD123 PE
1F-700-T025	Anti-Hu CD123 FITC
1B-700-C025	Anti-Hu CD123 Biotin
11-700-C025	Anti-Hu CD123 Purified
11-700-C100	Anti-Hu CD123 Purified
1A-700-T025	Anti-Hu CD123 APC