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Polygalaxanthone III

CAT: 0804-HY-N1407-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N1407-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Polygalaxanthone III is extracted from polygala tenuifolia wild, has inhibitory effect towards CYP450 enzyme. Polygalaxanthone III inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1 with an IC50 of 50.56 μM[1].
CAS Number
162857-78-5
UNSPSC
12352005
Hazard Statement
H302
Target
Cytochrome P450
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/polygalaxanthone-iii.html
Purity
99.28
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
COC1=C(O)C=C(OC(C=C(O)C([C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]3OC[C@@](CO)(O)[C@H]3O)O2)=C4O)=C4C5=O)C5=C1
Molecular Formula
C25H28O15
Molecular Weight
568.48
Precautions
H302
References & Citations
[1]Li ZL, et al. Effect of oligosaccharide esters and polygalaxanthone Ill from Polygala tenuifolia willd towards cytochrome P450. Zhongguo Zhong Yao Za Zhi. 2014 Nov;39 (22) :4459-63.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CYP2

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