Bcl-6 (Acetyl Lys379) rabbit pAb

Bcl-6 (Acetyl Lys379) rabbit pAb

• Description: Disease: A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t (3;11) (q27;q23) with POU2AF1/OBF1. Disease: A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t (3;4) (q27;p11) with ARHH/TTF. Disease: Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t (3;14) (q27;q32); translocation t (3;22) (q27;q11) with immunoglobulin gene regions. function: Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis. induction: Down-regulated during maturation of dendritic cells by selective stimuli such as LPS, CD40L and zymosan. PTM: Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway. similarity: Contains 1 BTB (POZ) domain. similarity: Contains 6 C2H2-type zinc fingers. subunit: Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9. tissue specificity: Expressed in germinal center T and B cells and in primary immature dendritic cells.
• Synonyms: B-cell lymphoma 6 protein (BCL-6;B-cell lymphoma 5 protein;BCL-5;Protein LAZ-3;Zinc finger and BTB domain-containing protein 27;Zinc finger protein 51)
• Gene ID: 604
• UniProt: P41182
• Cellular Locus: Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthesized peptide derived from human Bcl-6 (Acetyl Lys379)
• Clonality: Polyclonal
• Validated Applications: WB, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:1000-2000 ELISA 1:5000-20000
• Molecular Weight: 80kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.